Tag: pharmacology

Psychology 101: Emotions – Why Do We Feel the Way We Do? James-Lange Theory vs Cannon Bard Theory vs Two-Factor Theory

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When we are met with sudden bursts of emotions, what comes first: the physical or mental reaction? 

Since the inception of psychology, emotions have turned into an interesting chicken or the egg phenomena. When good things happen, we smile, but does smiling make us happier? 

In the world of psychology and motor neurons, these questions remain unanswered, but countless theories have arisen to explain this almost unexplainable human characteristic. These theories have tried to distinguish the specific firing point within our bodies regarding these emotions, but all of them lack an explanation broad enough that can effectively describe such a diverse human race. 

Emotions are a complex mixture of our physical, cognitive, and expressive behavior, but to what extent do each of these matter? Of course, when good, positive things happen to us, we feel a gut-reaction, whether that be smiling or laughing. All of these reactions happen both beneath our skin and within our neurons while also being presented outward and physically.

Immunology 101: Stages of B-cell Development [Biology, MCAT, USMLE Medicine]

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B-Cell Development Stages. stem cell –> early pro-B cell –> late pro-B cell –> large pre-B cell –> [1st checkpoint – selects for functional heavy chains] –> small pre-B cell –> [2nd checkpoint – select for functional light chains] –> Immature B cell (has surface IgM, no surface IgD). Somatic recombination is the process in which different individual gene segments of the H (heavy) chain combine with rearranged gene segments of the L (light) chain. The enzymes responsible for somatic recombination are the recombinase enzymes (RAG-1 and RAG-2) that recognize specific sequences (RSS) or recombination signal sequences. RAG-1 and RAG-2 are only expressed in B or T lymphocytes. These specific sequences recognized by the RAG-1 or RAG-2 enzymes are either a 1) heptamer or 2) nonamer. The heptamer literally contains 7 nucleotides, and the nonamer literally contains 9 nucleotides. There are typically 12 or 23 nucleotides in between the heptamer and nonamer to separate them.

Digoxin: How does Digoxin treat heart failure? Mechanism of Action and Side Effects [USMLE, Biology, MCAT, Medicine]

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Digoxin is a drug that treats heart arrhythmias, left ventricular systolic dysfunction, and heart failure. In this succinct educational lesson, we learn about how digoxin works in treating heart arrhythmias and heart failure, digoxin toxicity and common side effects, and treatment for digoxin toxicity. We also have a mini quiz at the end, so you can test your knowledge on the pharmacology of digoxin.

Immunology: Treatments for Rheumatoid Arthritis – NSAIDs vs DMARDs vs Glucocorticoids [Biology, Medicine, MCAT, USMLE]

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Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation in the joints of hands, feet, knees, etc. In this quick and easy lesson, we explain the standard medical treatment for patients with rheumatoid arthritis at the USMLE immunology level, including DMARDS (synthetics and biologics), NSAIDS, and glucocorticoids.